The use of statistics: references from Yann's seminar and the last issue of Nature

Here are the references of the papers on descriptive statistics cited by Yann during his seminar: 

- "Early-warning signals for critical transition", Scheffer, Nature, 2009
- "Anticipating critical transitions", Scheffer, Science, 2012
- "Recovery rates reflect distance to a tipping point in living systems", Veraart, Nature, 2012
- "Slower recovery in space before collapse of connected populations", Dai, Nature, 2013


And a must read in the last issue of Nature on the right use of the P value:

"When it comes to statistical analysis of experimental data, the piece says, most scientists would look at a P value of 0.01 and “say that there was just a 1% chance” of the result being a false alarm. “But they would be wrong.” In other words, most researchers do not understand the basis for a term many use every day. Worse, scientists misuse it. In doing so, they help to bury scientific truth beneath an avalanche of false findings that fail to survive replication." Nature editorial.

Some news on CRISPR

Two important articles on CRISPR now in monkey (link) and in Xenopus tropicalis (link)

New speaker invited by the department: Yves Barral

Yves Barral has accepted the department invitation and will be at IGDR on Nov 14th 2014 to give a seminar.

Some recent articles from his lab:
- Merlini, L., Fraschini, R., Boetscher, B., Barral, Y., Lucchini, G. and S. Piatti*, (2012), “Budding yeast Dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the Elm1 kinase to the bud neck”, PLoS Genet. 8:e1002670
- Hotz, M., Leisner, C., Chen, D., Manatschal, C., Wegleiter, T., Ouellet, J., Lindstrom, D., Gottschling, D., Vogel, J. and Y. Barral*, (2012) “Spindle pole bodies exploit the Mitotic Exit Network in metaphase to drive their age-dependent segregation”, Cell, 148:958-72
- Neurohr G, Naegeli A, Titos I, Theler D, Greber B, Díez J, Gabaldón T, Mendoza M, Barral Y. (2011) A midzone-based ruler adjusts chromosome compaction to anaphase spindle length. Science. Apr 22;332(6028):465-8
- Cannarozzi G, Schraudolph NN, Faty M, von Rohr P, Friberg MT, Roth AC, Gonnet P, Gonnet G, Barral Y. (2010) "A role for codon order in translation dynamics." Cell. Apr 16;141(2):355-67.

A follow up on the CRISPR round table: now in cell lines...

Two in press papers in Science show that CRISPR can now be done in human cells using lentiviral vectors. It has been done in HEK293T, in the melanoma cell line A375, in the stem cell line HUES62, in the HL60 pseudo-diploid human leukemic cell line, etc.

http://www.sciencemag.org.gate1.inist.fr/content/early/2013/12/11/science.1247005.full
http://www.sciencemag.org.gate1.inist.fr/content/early/2013/12/11/science.1246981.full

2013-2014 schedule

2013
 Nov 5          Round table on CRISPR - Grégoire Michaux
Nov 19        Jacques Pécréaux
Dec 3           Gwen Rabut
Dec 17        Jenny Wu

2014
Jan 14          Round table on super resolution - Marc Tramier
Jan 28          Régis Giet
Feb 11          Yann Le Cunff
Feb 25          Erwan Watrin
Mar 11         Christelle Benaud
Mar 25         Denis Chrétien
Apr 8            Nicolas Bigot (for Rémy Pedeux)
Apr 22          Jean-Pierre Tassan
May 6           No meeting
May 20         Yannick Arlot
June 3          Christian Jaulin
June 17        Damien Coudreuse